Cheng Research Lab

An-Lin Cheng, Ph.D., is an associate professor who joined the School of Nursing and Health studies in 2006. Cheng developed two online statistics courses for the nursing doctoral program. She mentors several doctoral students who conduct secondary data analysis as dissertation topics, and she also served as a dissertation committee member to many doctoral students who conducted quantitative related research. Cheng’s primary research interests involve statistical methodology development in the design and analysis of data from clinical trials, health promotion studies, bioinformatics, and genetic association studies (GWS) and secondary data analyses. She collaborates with researchers on several controlled studies and cross-sectional studies. She takes primary responsibility for all quantitative data analyses and has successfully applied sophisticated statistical models to identify intervention effects, or factors associated with enhanced quality of life or positive health outcomes among populations of vulnerable adults.

Two specific areas of Cheng’s expertise could have an important impact on the future research directions on MUBIG. The first area includes her ample expertise in applying multilevel hierarchical random effect models to cluster data with repeated measured categorical and continuous outcomes. Second, Cheng recently applied the structural equation modeling technique to study the possible moderators and mediators between the relationship of personality traits and muscle strength decline. However, her collaboration with MUBIG has already elevated her research to another level; groups have successfully conducted two meta-analyses to study potential driver genes for endometrial cancer and to study the effect of Bisphenol A on neuronal development. The same analytical technique will be applied to different disease areas or conditions, such as sarcopenia.

Innovative Modeling Approaches for the Understanding of Gene Networks:

Network heat map of all genes altered by Bisphenol
Network heat map of all genes altered by Bisphenol
Visualization of newly discovered gene network in human endometrial cancer with the assistance of these developed in the Cheng lab
Visualization of newly discovered gene network in human endometrial cancer with the assistance of these developed in the Cheng lab

Funding

  • NIH Clinical and Translational Science Award grant: UL1RR033179 (PI)
  • National Institute on Aging: P01 1P01AG039355-01A1 (Co-I; Bonewald and Brotto PIs)
  • National Institute of Nursing Research: K01NR014409 (Co-I; Enriquez PI)
  • National Institute of Diabetes, Digestive and Kidney Disease: R01 DK93592-01A1  (Co-I; Russell PI)
  • National Institute of Minorities and Health Disparities Small Business Incentives Research (Co-I; Hunter PI)
  • Department of Defense (Co-I; Kelly PI)
  • Organization of Autism Research (Co-I; Roberts PI)

Selected Publications

Cheng, A., Kelly, P.J., McEvers, K., & Witt, J. (2014). The intention of advanced practice registered nurses to remain in positions at family planning clinics serving low-income women. Journal of Professional Nursing. 30, 72-79.

Chou, WC, Cheng, A, Brotto, M, and Chuang, CY. (2014) Visual Gene-Network Analysis Reveals the Cancer Gene Co-Expression in Human Endometrial Cancer. BMC Genomics. 15(1), 300-.

Yang, CW, Chou, WC, Chen, KH, Cheng, A, Mao, IF, Chao, HR, and Chuang, CY. (2014) Visualized Gene Network Reveals the Novel Target Transcripts Sox2 and Pax6 of Neuronal Development in Trans-placental Exposure to Bisphenol A. PLOS ONE

Kelly, P.J., Cheng, A., Spencer-Carver, E., and Ramaswamy, M. (2014) A Syndemic Model of Women Incarcerated in Community Jail. Public Health Nursing. 31, 118-125.

Enriquez, M., Kelly, P.J., Cheng, A., Hunter, J., & Mendez E. (2012). An intervention to address interpersonal violence among low-income Midwestern Hispanic-American teens. Journal of Immigrant and Minority Health, 14(2), 292-299. PMID: 21573749.

Cheng, A. & Kelly, P.J. (2011). Application of a hierarchical model incorporating intra-family correlation and cluster effects. Nursing Research, 60(3), 208-212. PMCID: PMC3087840.

Enriquez, M., Cheng, A., Kelly, P.J., Witt, J., Coker A. & Kashubeck-West, S. (2010). Development and feasibility of an HIV and IPV prevention intervention among low-income mothers receiving services in a Missouri daycare center. Violence Against Women, 16(5), 560-578. PMID: 20388931.

Enriquez, M., Cheng, A., McKinsey, D. & Stanford, J. (2009). Development and efficacy of an intervention to enhance readiness for adherence among adults who had previously failed HIV treatment.  AIDS Patient Care and STDs, 23(3), 177-184. PMID: 19866535.

Kelly, P.J., Cheng, A., Peralez-Dieckmann, E. & Martinez, E. (2009).  Dating violence and girls in the juvenile justice system.  Journal of Interpersonal Violence, 24(9), 1536-1551.  PMID: 18768739.

Cheng, A., Lin, H., Kasprow, W., & Rosenheck, R. (2007).  Impact of supported housing on clinical outcomes: analysis of a randomized trial using multiple imputation technique.  Journal of Nervous and Mental Disease, 195(1), 83-88. PMCID: PMC3073142.